Dopa decarboxylase, an enzyme involved in the synthesis of the neurotransmitter dopamine, catalyses the formation of functional dopamine through decarboxylation of a precursor tyrosine derivative. In ...

Aromatic amino acid decarboxylase (AADC) deficiency is a rare, autosomal recessively inherited neurometabolic disorder characterised by markedly reduced synthesis of key monoamine neurotransmitters ...

Kebillidi is the first gene therapy to gain FDA approval for the treatment of aromatic L-amino acid decarboxylase deficiency. The FDA has approved PTC Therapeutics’ Kebillidi (eladocagene ...