According to Blakely, unlike the sharp rise in dopamine that triggers euphoria and can lead to addiction, dopamine that dribbles out through a leaky transporter makes it hard for a receptive brain ...

The dopamine transporter (DAT) is integral to the regulation of synaptic dopamine levels, a process central to the maintenance of normal neurological function. DAT not only mediates the reuptake of ...

Researchers have discovered a potentially safer yet effective treatment for multiple disorders that display altered dopamine signaling. The “key?” A molecule that targets a specific protein called the ...

With the help of a tiny, transparent worm called Caenorhabditis elegans, researchers have identified novel players in dopamine signaling by taking advantage of a powerful platform generated via the ...

Methamphetamine addiction has a way of looping back on itself. A rush of pleasure pulls you in, cravings follow, and the brain learns that the drug is the fastest route to reward. Yet scientists still ...

For the first time, researchers are able to describe how the dopamine transporter involved in cocaine use operates at the molecular level, which could pave the way to future targeted treatments.

Dopamine, a powerful brain chemical and neurotransmitter, is a key regulator of many important functions such as attention, experiencing pleasure and reward, and coordinating movement. The brain ...

You have probably heard of dopamine. The substance also known as the "feel-good hormone". Drugs such as cocaine cause a surge of dopamine in the brain. Normally, a protein in the brain called the ...

University of Florida neuroscientists have made a mechanistic discovery that paves the way to test immune-modulating medicines as a potential tool to break the cycle of methamphetamine addiction.

Dopamine doesn’t flood the brain as once believed – it fires in exact, ultra-fast bursts that target specific neurons. The discovery turns a century-old view of dopamine on its head and could ...

Dopamine is the brain's motivational spark, driving us to chase what feels good, say scrolling another reel on social media, and steer clear of what doesn't, like touching a hot stove. But scientists ...