Researchers have used a combination of genetic manipulation and protein structural analysis to determine how the position of 'bulky' amino acids influences the ability of efflux pump inhibitors to ...

Different types of efflux pump proteins might have evolved independently, instead of divergently as previously thought. This could yield insights in mediating antibiotic resistance. Different types of ...

It's no wonder that medicine's effort to combat bacterial infections is often described as an arms race. When new drugs are developed to combat infections, the bacterial target invariably comes up ...

A functional impairment of hepatobiliary transporters such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP2) are strongly associated with an increased risk of liver ...

Besides their normal role, pump overexpression confers drug resistance. Knowing the structure is a step to disabling the pumps with inhibitors BIRMINGHAM, Ala. – Tuberculosis is the world’s leading ...

Scientists at Fujifilm Corp. and Osaka University have described piperazine derivatives acting as drug efflux pump inhibitors reported to be useful for the treatment of bacterial infections.

image: The inhibitor-binding site of the wild-type MexB pump. (a) The crystal structure of the inhibitor ABI-PP bound to the MexB trimer. Three MexB monomers are shown in green, blue, and red, ...