Cancer immunotherapy has transformed modern oncology by harnessing body's own immune system to combat malignant disease.

The GINECO window-of-opportunity COLIBRI (NCT04256213) study provides compelling evidence that a neoadjuvant "priming" dose ...

Immune checkpoint inhibitor (ICI) pneumonitis is a potentially life-threatening immune-related adverse event associated with ICI therapy across various malignancies. ICIs enhance antitumour immunity ...

Dozens of drugs can alter the immune system and affect activity of immune checkpoint inhib ...

Cancer immunotherapy has transformed modern oncology by harnessing the body's own immune system to combat malignant disease. Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have produced ...

Scientists at the Icahn School of Medicine at Mount Sinai have identified an important immune response that helps explain why ...

More than two-thirds of deaths from ovarian cancer are attributable to high-grade serous carcinoma. In one particularly aggressive form, only a small number of inactive immune cells can be found near ...

Immune system activation and activity is regulated through stimulatory or inhibitory ligand-receptor interactions collectively termed immune checkpoints. 1 Stimulatory interactions give the immune ...

Among modern cancer therapies, immune checkpoint inhibitors (ICI) are among the most successful treatment methods. These ...

Cell cycle checkpoint-related genes (CCCRGs) are implicated in the development and progression of hepatocellular carcinoma (HCC). However, their precise roles and underlying mechanisms remain ...