The term 'allograft' refers to a cell, tissue, or organ transplant between two genetically distinct (i.e., 'allogeneic') members of the same species. The primary basis for allograft rejection is the ...
Human leukocyte antigen (HLA) typing is important in organ transplantation protocols, as they determine the likelihood of rejection. The HLA system is little understood, however. In simple terms, the ...
Particular major histocompatibility complex (MHC) class II alleles clearly contribute to T cell-mediated autoimmune type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice. However, ...
HLA-G is a nonclassical MHC class I (MHCI) molecule that can suppress a wide range of immune responses in the maternal-fetal interface. The human inhibitory immune receptors leukocyte Iglike receptor ...
In a recent article posted to the bioRxiv* preprint server, researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major ...
Clinical utilization of precision oncology decision support for genomically-informed cancer therapy. PD-1, PD-L1, and B7-H3 expression in Human Immunodeficiency Virus (HIV) infected patients with ...
Maturation of the lymphoid system occurs during the fetal and neonatal periods when lymphoid stem cells differentiate into B cells or T cells. At this time, the mechanisms for conferring genetic ...
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