In a recent study published in the IUBMB journal, researchers assessed the association between platelet-activating factor (PAF) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ...

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis. The ...

The contractile responses of esophageal smooth muscle (SM) induced by platelet-activating factor (PAF) involve the activation of L-type voltage-dependent calcium channels (L-type VDCCs), ...

PAF causes strong contractions—especially in the muscles of the esophagus and the stomach’s upper region (called the gastric fundus). In other parts of the intestine, such as the small intestine and ...

Eighty-eight patients were randomised and included in the study (BN 52021: 44; placebo: 44) and received at least one dose of the study medication (figure 1). These 88 patients were included in the ...

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has ...

A research group has uncovered important details about how platelet-activating factor (PAF)—a powerful molecule involved in inflammation and allergic reactions—triggers contractions in the smooth ...

Experimental and clinical studies suggest that PAF antagonists like BN 52021 appear to be effective in cases of severe Gram-negative septic shock. [6] The outcome of the present multicentre study in ...