A group of international researchers reports the availability of a new “map”’ of every gene, protein, and metabolic pathway required for a cell to efficiently secrete recombinant proteins. The team, ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson’s disease protein
Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...
snoRNAs were thought simply to guide chemical modifications to rRNAs, but a new technique has revealed a suite of potential functions in protein secretion. A recent research effort from the University ...
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
Dry eye disease happens when the lacrimal glands do not make enough tears, or the tears do not have the right balance of ingredients to protect the eye surface. Tears are not just “water”. They help ...
Researchers at the University of Chicago have developed a technology for identifying new cellular RNA targets of small nucleolar RNAs (snoRNAs), a common but overlooked group of guide RNA molecules ...
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