This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

"Alterations in axonal membrane and channel function occur early in the disease course, prior to discernable large fibre involvement, and has the potential to be used as an early biomarker of ...

Each of the individual paraproteinemic disorders exhibits a distinct neuropathic phenotype, and the typical clinical features are described below. The prognosis is often not well-defined and unknown ...

Hereditary sensory and autonomic neuropathies (HSANs) are a clinically and genetically heterogeneous group of disorders of the PNS. Progressive degeneration, predominantly of sensory and autonomic ...

Sensory nerve action potential amplitudes decreased as patients aged in a cohort of spinal muscular atrophy (SMA) type 1 patients compared with a healthy, age-matched control group. Spinal muscular ...

Small fiber sensory neuropathy is a neuromuscular disorder that affects millions of people. It can be caused by various conditions, such as diabetes or prediabetes. It can also occur on its own. Main ...

The latest reports come from 2 separate European groups. Dr C Metzler (University Hospital of Schleswig-Holstein, Luebeck, Germany) and colleagues told the British Society of Rheumatology meeting how ...

An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit ...

Laryngeal sensory neuropathy affects the nerves in the larynx, or the voice box. This area of the throat contains the vocal cords and has a role in breathing, swallowing, and talking. Laryngeal ...

A 56-year-old woman presents to the hospital complaining of generalized weakness that has been progressing for the past month. Her initial symptoms involved numbness and weakness in her legs and lower ...

Hannah’s Hope is a charity that was formed in 2008 after then-Plattsburgh residents Lori and Matt Sames’ daughter was diagnosed with a rare progressive nerve disease. Known informally as GAN, the ...