The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, ...

Telomere is a repeated sequence (TTAGGG)N that caps the end of the chromosomes to protect them from damage during DNA replication prior to cell division. Telomere length is essential to the cell's ...

Case Comprehensive Cancer Center-led research has potential for development of new cancer treatment targets. Research published in “Science Signaling” identifies new ways that telomeres regulate the ...

The number of times our cells can divide is dictated by telomeres, stretches of DNA at the tips of our chromosomes. Understanding how telomeres keep our chromosomes – and by extension, our genomes – ...

In absence of TARG1, ADP-ribose accumulated at telomeres, leading to disruption of telomere replication and premature telomere shortening. To show that these telomere defects were due to modification ...

New findings describe how the enzyme CST is recruited to the end of the telomere, where it maintains telomere length with the help of subtle chemical changes made to the protein POT1. The length of ...

CST (purple/lavender) bound to POT1 (red). Phosphorylation of the crimson-highlighted region in POT1 regulates the recruitment and activity of CST–Polα-primase at telomeres. The length of telomeres ...