Monday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Indianapolis Colts NFL ...

It's the San Francisco 49ers vs Indianapolis Colts on Monday Night Football in Week 16 of the 2025 NFL season. Here's how to watch, including time, TV channel and streaming info.

For the 29th time in franchise history, the San Francisco 49ers have notched 10-plus wins in a season. Following a rare December bye week, the 49ers posted a 37-24 victory over the Tennessee Titans.

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