Atherosclerosis is a lipid-driven chronic inflammatory disease that is modulated by innate and adaptive immunity including humoral immunity. Importantly, antibody alterations achieved by genetic means ...

The intellectual property will enhance Liberate Bio’s LNP platform for selective programming of monocytes and macrophages.

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

Please provide your email address to receive an email when new articles are posted on . CTx001 is an investigational adeno-associated virus-based therapy for geographic atrophy. Patient dosing in the ...

FDA Fast Track designation has been granted to CTx001 for Geographic Atrophy secondary to Age-related Macular Degeneration CTx001 is an investigational AAV-based gene therapy designed to modulate ...

Scientists have spotted a new variety of riled-up microglia that drives swelling in the human brain. In the November 18 Neuron, researchers from China led by Haixiao Liu, Shunnan Ge, and Yan Qu at ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

Three distinct snapshots obtained with cryo-electron microscopy illustrate the arrangement of two of the four symmetrical subunits that make a functional NMDA receptor. During activation, as the ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The complement 3a receptor (C3aR) is a G-protein-coupled receptor (GPCR) involved in ...

Individuals who develop antibodies against the GluN1 subunit of NMDA receptors can develop NMDA receptor encephalitis (NMDARE), which can lead to psychosis, cognitive deficits and movement disorders.

Therapeutic antibodies, especially polyclonal antibodies, are indispensable in contemporary medicine for addressing a broad spectrum of conditions, including infectious diseases, autoimmune disorders, ...